chemical compounds Search Results


hts compound collection  (Life Chemicals Inc)
94
Life Chemicals Inc hts compound collection
Hts Compound Collection, supplied by Life Chemicals Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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endoplasmic reticulum er stress agonist tunicamycin  (Selleck Chemicals)
93
Selleck Chemicals endoplasmic reticulum er stress agonist tunicamycin
ER stress agonist reverses the effects of Apelin-13 on oxidative stress and apoptosis. HEI-OC1 cells were pretreated with TM to stimulate ER stress, and (A) the impacts of TM on oxidative stress were determined by measuring indicators. (B) Flow cytometry revealed the proportion of apoptotic cells. (C) Quantitative results of flow cytometry. (D) Caspase3 kit revealed intracellular caspase3 activity. *** P<0.001 vs. control; ### P<0.001 vs. HG; & P<0.05, && P<0.01 and &&& P<0.001 vs. HG + Apelin-13. ER, <t>endoplasmic</t> reticulum; TM, <t>tunicamycin;</t> HG, high glucose.
Endoplasmic Reticulum Er Stress Agonist Tunicamycin, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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drugs  (Selleck Chemicals)
95
Selleck Chemicals drugs
ER stress agonist reverses the effects of Apelin-13 on oxidative stress and apoptosis. HEI-OC1 cells were pretreated with TM to stimulate ER stress, and (A) the impacts of TM on oxidative stress were determined by measuring indicators. (B) Flow cytometry revealed the proportion of apoptotic cells. (C) Quantitative results of flow cytometry. (D) Caspase3 kit revealed intracellular caspase3 activity. *** P<0.001 vs. control; ### P<0.001 vs. HG; & P<0.05, && P<0.01 and &&& P<0.001 vs. HG + Apelin-13. ER, <t>endoplasmic</t> reticulum; TM, <t>tunicamycin;</t> HG, high glucose.
Drugs, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 95 stars, based on 1 article reviews
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epigenetics compound library  (Selleck Chemicals)
94
Selleck Chemicals epigenetics compound library
ER stress agonist reverses the effects of Apelin-13 on oxidative stress and apoptosis. HEI-OC1 cells were pretreated with TM to stimulate ER stress, and (A) the impacts of TM on oxidative stress were determined by measuring indicators. (B) Flow cytometry revealed the proportion of apoptotic cells. (C) Quantitative results of flow cytometry. (D) Caspase3 kit revealed intracellular caspase3 activity. *** P<0.001 vs. control; ### P<0.001 vs. HG; & P<0.05, && P<0.01 and &&& P<0.001 vs. HG + Apelin-13. ER, <t>endoplasmic</t> reticulum; TM, <t>tunicamycin;</t> HG, high glucose.
Epigenetics Compound Library, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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chemical compound  (Selleck Chemicals)
96
Selleck Chemicals chemical compound
ER stress agonist reverses the effects of Apelin-13 on oxidative stress and apoptosis. HEI-OC1 cells were pretreated with TM to stimulate ER stress, and (A) the impacts of TM on oxidative stress were determined by measuring indicators. (B) Flow cytometry revealed the proportion of apoptotic cells. (C) Quantitative results of flow cytometry. (D) Caspase3 kit revealed intracellular caspase3 activity. *** P<0.001 vs. control; ### P<0.001 vs. HG; & P<0.05, && P<0.01 and &&& P<0.001 vs. HG + Apelin-13. ER, <t>endoplasmic</t> reticulum; TM, <t>tunicamycin;</t> HG, high glucose.
Chemical Compound, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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epz5676  (Selleck Chemicals)
94
Selleck Chemicals epz5676
ER stress agonist reverses the effects of Apelin-13 on oxidative stress and apoptosis. HEI-OC1 cells were pretreated with TM to stimulate ER stress, and (A) the impacts of TM on oxidative stress were determined by measuring indicators. (B) Flow cytometry revealed the proportion of apoptotic cells. (C) Quantitative results of flow cytometry. (D) Caspase3 kit revealed intracellular caspase3 activity. *** P<0.001 vs. control; ### P<0.001 vs. HG; & P<0.05, && P<0.01 and &&& P<0.001 vs. HG + Apelin-13. ER, <t>endoplasmic</t> reticulum; TM, <t>tunicamycin;</t> HG, high glucose.
Epz5676, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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compound c s7306  (Selleck Chemicals)
95
Selleck Chemicals compound c s7306
ER stress agonist reverses the effects of Apelin-13 on oxidative stress and apoptosis. HEI-OC1 cells were pretreated with TM to stimulate ER stress, and (A) the impacts of TM on oxidative stress were determined by measuring indicators. (B) Flow cytometry revealed the proportion of apoptotic cells. (C) Quantitative results of flow cytometry. (D) Caspase3 kit revealed intracellular caspase3 activity. *** P<0.001 vs. control; ### P<0.001 vs. HG; & P<0.05, && P<0.01 and &&& P<0.001 vs. HG + Apelin-13. ER, <t>endoplasmic</t> reticulum; TM, <t>tunicamycin;</t> HG, high glucose.
Compound C S7306, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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278 gpcr compounds  (Selleck Chemicals)
92
Selleck Chemicals 278 gpcr compounds
ER stress agonist reverses the effects of Apelin-13 on oxidative stress and apoptosis. HEI-OC1 cells were pretreated with TM to stimulate ER stress, and (A) the impacts of TM on oxidative stress were determined by measuring indicators. (B) Flow cytometry revealed the proportion of apoptotic cells. (C) Quantitative results of flow cytometry. (D) Caspase3 kit revealed intracellular caspase3 activity. *** P<0.001 vs. control; ### P<0.001 vs. HG; & P<0.05, && P<0.01 and &&& P<0.001 vs. HG + Apelin-13. ER, <t>endoplasmic</t> reticulum; TM, <t>tunicamycin;</t> HG, high glucose.
278 Gpcr Compounds, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cambridge cancer compound library  (Selleck Chemicals)
93
Selleck Chemicals cambridge cancer compound library
ER stress agonist reverses the effects of Apelin-13 on oxidative stress and apoptosis. HEI-OC1 cells were pretreated with TM to stimulate ER stress, and (A) the impacts of TM on oxidative stress were determined by measuring indicators. (B) Flow cytometry revealed the proportion of apoptotic cells. (C) Quantitative results of flow cytometry. (D) Caspase3 kit revealed intracellular caspase3 activity. *** P<0.001 vs. control; ### P<0.001 vs. HG; & P<0.05, && P<0.01 and &&& P<0.001 vs. HG + Apelin-13. ER, <t>endoplasmic</t> reticulum; TM, <t>tunicamycin;</t> HG, high glucose.
Cambridge Cancer Compound Library, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti infection library l3100  (Selleck Chemicals)
93
Selleck Chemicals anti infection library l3100
ER stress agonist reverses the effects of Apelin-13 on oxidative stress and apoptosis. HEI-OC1 cells were pretreated with TM to stimulate ER stress, and (A) the impacts of TM on oxidative stress were determined by measuring indicators. (B) Flow cytometry revealed the proportion of apoptotic cells. (C) Quantitative results of flow cytometry. (D) Caspase3 kit revealed intracellular caspase3 activity. *** P<0.001 vs. control; ### P<0.001 vs. HG; & P<0.05, && P<0.01 and &&& P<0.001 vs. HG + Apelin-13. ER, <t>endoplasmic</t> reticulum; TM, <t>tunicamycin;</t> HG, high glucose.
Anti Infection Library L3100, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bioactive small molecules  (Selleck Chemicals)
95
Selleck Chemicals bioactive small molecules
ER stress agonist reverses the effects of Apelin-13 on oxidative stress and apoptosis. HEI-OC1 cells were pretreated with TM to stimulate ER stress, and (A) the impacts of TM on oxidative stress were determined by measuring indicators. (B) Flow cytometry revealed the proportion of apoptotic cells. (C) Quantitative results of flow cytometry. (D) Caspase3 kit revealed intracellular caspase3 activity. *** P<0.001 vs. control; ### P<0.001 vs. HG; & P<0.05, && P<0.01 and &&& P<0.001 vs. HG + Apelin-13. ER, <t>endoplasmic</t> reticulum; TM, <t>tunicamycin;</t> HG, high glucose.
Bioactive Small Molecules, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cas antiviral set  (Selleck Chemicals)
93
Selleck Chemicals cas antiviral set
ER stress agonist reverses the effects of Apelin-13 on oxidative stress and apoptosis. HEI-OC1 cells were pretreated with TM to stimulate ER stress, and (A) the impacts of TM on oxidative stress were determined by measuring indicators. (B) Flow cytometry revealed the proportion of apoptotic cells. (C) Quantitative results of flow cytometry. (D) Caspase3 kit revealed intracellular caspase3 activity. *** P<0.001 vs. control; ### P<0.001 vs. HG; & P<0.05, && P<0.01 and &&& P<0.001 vs. HG + Apelin-13. ER, <t>endoplasmic</t> reticulum; TM, <t>tunicamycin;</t> HG, high glucose.
Cas Antiviral Set, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


ER stress agonist reverses the effects of Apelin-13 on oxidative stress and apoptosis. HEI-OC1 cells were pretreated with TM to stimulate ER stress, and (A) the impacts of TM on oxidative stress were determined by measuring indicators. (B) Flow cytometry revealed the proportion of apoptotic cells. (C) Quantitative results of flow cytometry. (D) Caspase3 kit revealed intracellular caspase3 activity. *** P<0.001 vs. control; ### P<0.001 vs. HG; & P<0.05, && P<0.01 and &&& P<0.001 vs. HG + Apelin-13. ER, endoplasmic reticulum; TM, tunicamycin; HG, high glucose.

Journal: Experimental and Therapeutic Medicine

Article Title: Apelin‑13 reduces high glucose‑induced mitochondrial dysfunction in cochlear hair cells by inhibiting endoplasmic reticulum stress

doi: 10.3892/etm.2024.12515

Figure Lengend Snippet: ER stress agonist reverses the effects of Apelin-13 on oxidative stress and apoptosis. HEI-OC1 cells were pretreated with TM to stimulate ER stress, and (A) the impacts of TM on oxidative stress were determined by measuring indicators. (B) Flow cytometry revealed the proportion of apoptotic cells. (C) Quantitative results of flow cytometry. (D) Caspase3 kit revealed intracellular caspase3 activity. *** P<0.001 vs. control; ### P<0.001 vs. HG; & P<0.05, && P<0.01 and &&& P<0.001 vs. HG + Apelin-13. ER, endoplasmic reticulum; TM, tunicamycin; HG, high glucose.

Article Snippet: For mechanistic studies, HEI-OC1 cells were pretreated with the endoplasmic reticulum (ER) stress agonist tunicamycin (TM; 5 μg/ml; Selleck Chemicals) for 6 h.

Techniques: Flow Cytometry, Activity Assay, Control

ER stress agonist reverses the effects of Apelin-13 on mitochondrial dysfunction. (A) The impacts of TM on mitochondrial membrane potential as reflected by JC-1 probes (magnification, x200. (B) The impacts of TM on mtROS production as reflected by MitoSOX Red probes (magnification, x200). (C) The impacts of TM on ATP production. *** P<0.001 vs. control; ### P<0.001 vs. HG; &&& P<0.001 vs. HG + Apelin-13. ER, endoplasmic reticulum; TM, tunicamycin; mtROS, mitochondrial reactive oxygen species; HG, high glucose.

Journal: Experimental and Therapeutic Medicine

Article Title: Apelin‑13 reduces high glucose‑induced mitochondrial dysfunction in cochlear hair cells by inhibiting endoplasmic reticulum stress

doi: 10.3892/etm.2024.12515

Figure Lengend Snippet: ER stress agonist reverses the effects of Apelin-13 on mitochondrial dysfunction. (A) The impacts of TM on mitochondrial membrane potential as reflected by JC-1 probes (magnification, x200. (B) The impacts of TM on mtROS production as reflected by MitoSOX Red probes (magnification, x200). (C) The impacts of TM on ATP production. *** P<0.001 vs. control; ### P<0.001 vs. HG; &&& P<0.001 vs. HG + Apelin-13. ER, endoplasmic reticulum; TM, tunicamycin; mtROS, mitochondrial reactive oxygen species; HG, high glucose.

Article Snippet: For mechanistic studies, HEI-OC1 cells were pretreated with the endoplasmic reticulum (ER) stress agonist tunicamycin (TM; 5 μg/ml; Selleck Chemicals) for 6 h.

Techniques: Membrane, Control